RESEARCH

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Olaris Publishes 'Gadolinium-Based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-Based Metabolomics'

Gadolinium is a paramagnetic relaxation enhancement (PRE) agent that accelerates the relaxation of metabolite nuclei. In this study, we noted the ability of gadolinium to improve the sensitivity of two-dimensional, non-uniform sampled NMR spectral data collected from metabolomics samples. In time-equivalent experiments, the addition of gadolinium increased the mean signal intensity measurement and the signal-to-noise ratio for metabolite resonances in both standard and plasma samples. Gadolinium led to highly linear intensity measurements that correlated with metabolite concentrations. In the presence of gadolinium, we were able to detect a broad array of metabolites with a lower limit of detection and quantification in the low micromolar range. We also observed an increase in the repeatability of intensity measurements upon the addition of gadolinium. The results of this study suggest that the addition of a gadolinium-based PRE agent to metabolite samples can improve NMR-based metabolomics.

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Olaris Publishes 'Metabolite Biomarkers of Response (BoRs): Towards a fingerprint for the evolution of metastatic breast cancer' in Special Cancer Evolution Issue

Breast cancer is the most common cancer in women worldwide and despite improved treatment strategies, it persists as the second leading cause of death of women globally. Overall prognosis drops drastically once the cancer has metastasized, which is also associated with resistance to therapy. The evolution from a localized breast cancer to metastatic disease is complex and multifactorial. Metabolic reprogramming is a pre-requisite for this transition. In this graphical review, we provide an overview of altered metabolic pathways observed in metastatic breast cancer (mBC) and detail how metabolite biomarkers could serve as a novel class of precision medicine tools to improve the diagnosis, monitoring, and treatment of mBC.

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Olaris Presents "Plasma-based metabolic profiling in metastatic gastrointestinal stromal tumors (GIST)" at AACR 2021

The presentation, led by Olaris Metabolite Scientist Dr. Chandrashekhar Honrao, highlights the use of Olaris’ BoR platform to identify metabolic signatures correlated with overall survival and to predict response or resistance to treatment in patients with advanced GIST.  “Targeted treatments have revolutionized cancer care, especially for GIST. However, due to patient heterogeneity it remains challenging to know who will benefit from one therapy over another. This study is particularly exciting as we were able to demonstrate and validate in an independent set of patient samples that metabolite biomarkers either before treatment or during treatment can identify patients with favorable clinical outcomes” said Dr. Elizabeth O’Day, CEO and Founder of Olaris.

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Olaris publishes in special Non-Uniform Sampling issue of Magnetic Resonance in Chemistry

Dr. Elizabeth O'Day and Leslie Hoyt's paper on discusses the opportunity for NUS NMR metabolite in-vitro diagnostics- key tools that can accelerate the goals of precision medicine. 

The ease of sample preparation, quantification of metabolite levels for overlapping peaks often found in patient samples, and reproducibility afforded by NMR can be used to develop metabolite based diagnostics with NUS. This may serve to reduce the long acquisition time associated with NMR.  

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Olaris publishes paper in Journal of Metabolites

Olaris' paper was recently published in the Journal of Metabolites. The paper demonstrates the reproducibility of non-uniform sampling 2D NMR in metabolomics. 

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Olaris presents NMR-based Metabolomics Data at ENC

Olaris' will be presenting a poster and giving a talk at the ENC! The Experimental NMR Conference features innovative research in NMR spectroscopy and Olaris is very excited to share our recent studies on the power of NUS 13C 1H HSQC NMR. See the poster below. 

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Olaris announces findings from exploratory analysis of biomarkers that predict patient responsiveness to Trastuzumab therapy

Olaris’ metabolite profiling platform and machine learning algorithms have the potential to accurately indicate whether HER2-positive metastatic breast cancer patients will respond to trastuzumab therapy.

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Olaris Metabolite Scientist, Dr. Bo Zhang, published in Journal of Proteome Research

Research Dr. Zhang contributed to was published in the Journal of Proteome Research. They developed a method to better identify lipid molecules through 2D NMR and COLMAR Lipids Web Server. 

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Olaris presents poster at the San Antonio Breast Cancer Symposium

Olaris is thrilled to present at the SABCS! We are excited to learn from the world's top breast cancer oncologists and share the results of our recent study, "Pretreatment serum metabolome predicts PFS in first-line trastuzumab-treated metastatic breast cancer." Learn more about our findings here. 

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Olaris Metabolite Scientist, Dr. Bo Zhang, published in Analytical Chemistry

"Accurate and Efficient Determination of Unknown Metabolites in Metabolomics by NMR-Based Molecular Motif Identification" discusses the new SUMMIT method to identify chemical classes of metabolites, a critical tool in understanding patient health and disease. Read the paper here!

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Olaris Metabolite Scientist, Dr. Chandra Honrao, published in Nature Research

We are so proud of Dr. Honrao for his work in helping to discover a new antibiotic for Gram-negative pathogens, a notoriously difficult pathogen to target. In fact, the last development in antibiotics for Gram-negative bacteria was in the 1960s. The exciting discovery has the potential to be developed into new therapeutics. Read the paper here!